Class: Biological Therapy

Generic Name: Dasatinib
Trade Name: Sprycel®

How is this drug used? Dasatinib is FDA approved for the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia (CML) with resistance or intolerance to prior therapy including imatinib. Dasatinib is also approved for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy.

What is the mechanism of action? Dasatinib reduces the activity of one or more proteins that are responsible for the uncontrolled growth of leukemia cells in patients with CML or Ph+ ALL.

How is dasatinib given (administered)? Dasatinib is administered orally in the form of a tablet. The dose depends on the type and stage of leukemia. Dasatinib can be taken with or without a meal. Tablets should be swallowed whole.

How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with dasatinib. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.

What are the most common (occur in 10% or more of patients) side effects of treatment with dasatinib?

  • Fluid retention
  • Headache
  • Diarrhea
  • Fatigue
  • Shortness of breath
  • Musculoskeletal pain
  • Nausea
  • Skin rash
  • Infection
  • Bleeding
  • Low blood cell counts

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

What can patients do to help alleviate or prevent discomfort and side effects?

  • Pay careful attention to the physician’s instructions and inform the physician of any side effects.
  • Maintain adequate rest and nutrition.
  • If possible, avoid large crowds or people who are sick or not feeling well
  • Wash hands often to reduce the risk of infection.
  • Avoid activities that may cause injury or bruising.

Are there any special precautions patients should be aware of before starting treatment?

  • Patients should inform their physician of any other medication they are taking (whether prescription or over-the-counter, including vitamins, herbs, etc.) as they may interact with treatment.
  • Patients should inform their physician if they are pregnant, breastfeeding or planning a family in the near future. This drug may cause birth defects. It is important to use some kind of birth control while undergoing treatment. It is not known if dasatinib passes into breast milk.
  • Patients should inform their physician about all medical conditions, including heart problems, liver problems, or lactose intolerance.

When should patients notify their physician?

Tell your doctor if you experience any unusual symptoms. Notify your healthcare provider immediately if you experience fever, bleeding or bruising, swelling, weight gain, or increasing shortness of breath.

What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.

Copyright © 2010 CancerConnect Last updated 07/10.

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